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A Holy War, from ancient mythology, where the Goddess Athena and Hades have fought against each other while defending the earth repeatedly over the span of 200 years. The story takes place in 18th century Europe, 243 years prior to the original "Saint Seiya" Three small children, Tenma, Alone, and Sasha have all shared a very happy childhood together. Tenma who is quite aggressive but upstanding has moved to Sanctuary to become a saint. It is there that he is reunited with Sasha who is the sister of Alone and learns that she is the reincarnation of Goddess Athena. Alone, who is kind, gentle and loves painting was chosen for the body of enemy King Hades. Tenma eventually becomes a saint of Pegasus and engages in a fierce battle with his best friend Alone, the King of Hades. Pegasus Tenma, King Hades, and the Goddess Athena and through the twist of their 3 fates merge together which unfolds a prologue to the original Saint Seiya.

After the Saints' victory against Hades, Seiya is left wounded and motionless in a wheel chair with no possible chance of recovery. Athena's sister Artemis, the Virgin Goddess of the Moon and twin sister of Apollo, makes an elaborate proposal - to restore Seiya's physical health in exchange for the supremacy of Sanctuary. Athena accepts and Artemis and her "Knights of the Sky" swiftly take control of Sanctuary. Now Seiya and his fellow Bronze Saints combat the forces of Zeus to regain their homeland but it will not be so easy. Bronze Saints Hydra Ichi and Unicorn Jabu, and Silver Saint Ophiuchus Shaina have join forces with Artemis and Apollo.

Hades is planning to take over the world, to achieve that goal, he sends out deceased Gold Saints to take Athena's head. Seiya and the other Bronze Saints come to help but their help isn't appreciated by the remaining Gold Saints that are still alive. (Source: ANN)

Seiya and the rest of the Bronze and Gold Saints who have survived the Sanctuary battle have entered the world of the Dead. They are fighting to get to Hades and defeat him. (Source: ANN)

After the 12 Gold Saints sacrifice their lives to destroy the Wailing Wall, The Bronze Saints enter the deepest realm of the Underworld, Elysion, where they face off aganist Hades's two most powerful servants: The Twin Gods, Hypnos and Thanatos, before they can reach Hades for the final battle.